Asthma With Hypersecretion-associated Gene for Cystic Fibrosis (CF-asthma)

F

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Status

Completed

Conditions

Asthma

Treatments

Genetic: Asthma patients

Study type

Observational

Funder types

Other

Identifiers

NCT02558127
IIBSP-CFT-2014-68
ESR-15-10784 (Registry Identifier)

Details and patient eligibility

About

The combination of asthma and being a carrier of genetic variants (mutations and / or polymorphisms) in the CFTR gene variant would cause bronchial asthma with mucus hypersecretion. This phenotype is characterized by a more severe disease, in terms of control, quality of life, exacerbations and lung function, and a different asthma the bronchial hypersecretion without inflammatory phenotype.

Full description

Primary objective: Determine the presence of genetic variants (mutations and / or polymorphisms) of the CFTR gene in patients with asthma with or without bronchial mucus hypersecretion. Secondary objectives: To identify genetic variants (mutations and / or polymorphisms) of the most common CFTR gene in the asthmatic population. -To define the inflammatory phenotype of asthma with bronchial mucus hypersecretion. -To compare the severity, control, quality of life and frequency of exacerbations of asthma patients with or without bronchial mucus hypersecretion

Enrollment

100 patients

Sex

All

Ages

18 to 80 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria: Asthmatic patients aged between 18 and 80 years.They have not a respiratory infection in the last month.

Criteria for exclusion: Presence of other lung disease, Sequelae of tuberculosis, Bronchiectasis (large, secondary to a different asthma respiratory disease), Cystic fibrosis, Residual pleural disease, Interstitial diseases, Severe comorbidity, Patients with oral corticosteroids or other immunomodulators by causes other than asthma.

Trial design

100 participants in 2 patient groups

50 asthma patients
Description:
50 asthma patients with bronchial mucus hypersecretion
Treatment:
Genetic: Asthma patients
asthma patients
Description:
50 asthma patients without bronchial mucus hypersecretion
Treatment:
Genetic: Asthma patients

Trial contacts and locations

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Data sourced from clinicaltrials.gov

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