Astigmatism in Keratoconus Patients

Assiut University

Status: Unknown

Conditions: Keratoconus

Treatments: Device: Pentacam

Study type: Interventional

Funder types: Other

Identifiers

NCT03450213

Keratoconus

Details and patient eligibility

About

Keratoconus is a bilateral (but usually asymmetrical) non-inflammatory progressive thinning process of the cornea. It manifests as characteristic cone-like ectasia of the cornea associated with irregular stromal thinning, resulting in a cone-like bulge , which causing irregular astigmatism and vision impairment.

Full description

Keratoconus is the most common form of corneal ectasia, with an incidence of 50-230 per 100,000 persons.Pentacam used diagnose & detect the progression in patients with keratoconus and also provide a detailed information about corneal tomography and topography.

In the last few years, it has been shown that in healthy individuals the posterior corneal surface has not only a different amount of astigmatism but also a different alignment of the steep meridian.

The aim of this research is to compare the amount and axis alignment of anterior and posterior corneal astigmatism in keratoconus with a healthy controlled group .

Enrollment: 100 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients diagnosed with keratoconus using the following criteria:

Specific diagnostic signs is asymmetric refractive errors with high progressive or irregular astigmatism, and elevated keratometry values, scissoring of the red reflex, Vogt striae, Fleischer rings, inferior or central steepening on topography with abnormal localized steepening .

Exclusion criteria

• Unwillingness to participate in the study .
• Corneal scarring.
• Any ectatic conditions that were not explicitly keratoconus such as keratoglobus and pellucid marginal degeneration .
• Previous ocular surgery.

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups, including a placebo group

Patients with keratoconus

Active Comparator group

Description:

Pentacam will be used for comparison between astigmatism in patients with keratoconus and normal people at the same age and sex.

Treatment:

Device: Pentacam

Normal people at the same age and sex

Placebo Comparator group

Description:

Pentacam will be used for comparison between astigmatism in patients with keratoconus and normal people at the same age and sex.

Treatment:

Device: Pentacam