Asymptomatic Primary Hyperparathyroidism: A Prospective, Randomized Trial (SIPH)

University of Oslo (UIO)

Status: Completed

Conditions: Primary Hyperparathyroidism

Study type: Observational

Funder types: Other

Identifiers

NCT00522028

S-96107 (REK)

9571 (NSD) (Other Identifier)

Details and patient eligibility

About

The present study is a randomized, controlled trial that investigates the effects of parathyroidectomy or medical observation in mild asymptomatic pHPT on morbidity and quality of life (QoL).

Full description

The patients are included and randomized by block randomization to medical observation or parathyroidectomy by an experienced parathyroid surgeon.

The patients will be followed up for 10 years.

Enrollment: 191 patients

Sex: All

Ages: 50 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Untreated, asymptomatic pHPT
• 2.60>S-Ca<2.85 mmol/liter
• Age between 50 and 80 yr
• No medications interfering with Ca-metabolism
• Informed consent

Exclusion criteria

• Hyperparathyroid bone disease
• Previous operation in the neck
• Impaired kidney function
• Kidney stones
• Complicating medical conditions
• Psychiatric disorders
• Multiple endocrine neoplasia,
• Familial hypocalcuric hypercalcemia
• Familial HPT