Atopy Network - Comprehensive Allergy Centers: Medical Care of Patients With Moderate to Severe Allergic Diseases (ATAC)

Charité University Medicine Berlin

Status: Enrolling

Conditions: Atopic Disorders

Treatments: Other: not applicable, observational study

Study type: Observational

Funder types: Other

Identifiers

NCT05334940

Atopy Registry

Details and patient eligibility

About

The Atopy Registry aims to assess data about atopic disorders and their medical care in a standardized form. With this, the comparative efficacy, tolerability and safety of systemic therapies for atopic disorders should be investigated. An optional additional module "Bioanalytic" shall provide insights into further connections regarding immunology, genetics and microbiome.

Full description

The prevalence of atopic disorders increased in the western countries within the past decades. Atopic disorders are among others: food allergy, atopic dermatitis, allergic rhinitis, bronchial asthma, chronic spontaneous urticaria, eosinophilic esophagitis and chronic rhinosinusitis with nasal polyposis.

Seriously affected patients often have coexisting atopic disorders. In fact, 60-75% of the patients with a severe atopic dermatitis also suffer from an allergic rhinoconjunctivitis and 40-50% from bronchial asthma. This leads to a decreased quality of life (LG) especially in seriously affected patients.

The treatment of atopic disorders is not standardized yet. The Atopy Registry should promote the creation of a Germany-wide registry for different atopic disorders.Furthermore, the registry should characterize the medical care of patients with atopic disorders (patient satisfaction, therapy order, treatment success). This study serves as a longterm observation und is designed to compare different systemic therapies, since head-to-head studies regarding the efficacy are still missing. The analysis of biomaterial is involved to state possible correlations between endotype and phenotype.

Enrollment: 600 estimated patients

Sex: All

Ages: 6+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients are at least 6 years old
• patients with a proven moderate to severe atopic disorder who are planned to receive a biologic systemic therapy
• at least one additional proven atopic disorder

Exclusion criteria

• <2 atopic disorders
• poor compliance
• pregnancy or breastfeeding

Trial design

600 participants in 1 patient group

Atopic disorders

Description:

Patients with at least 2 atopic disorders who are eligible for systemic therapy with biologics

Treatment:

Other: not applicable, observational study