Atorvastatin as an Antihypertensive Agent

Himayat Ullah

Status: Completed

Conditions: Atorvastatin Antihypertensive Effect

Treatments: Drug: Amlodipine 5 MG / Atorvastatin 10 MG Oral Tablet; Drug: Amlodipine 5 MG Oral Tablet

Study type: Interventional

Funder types: Other

Identifiers

NCT05679102

DIR/KMU-EB/EA/000560

Details and patient eligibility

About

This study is aimed to see the antihypertensive effect of statin (Atorvastatin) as certain animal models have shown that statins have the voltage-gated calcium channel blocking effect. It will be a randomized controlled trial that will be done in Ayub Hospital Complex Abbottabad. After ethical approval, 120 patients with newly diagnosed hypertension belonging to either gender and aged 35 and above will be enrolled in the trial. They will randomly be grouped into two groups with each group comprising 60 patients. One group will be administered Amlodipine 5 mg PO once a day, while the other one will be given 5mg Amlodipine plus 10 mg Atorvastatin. The patients will be examined on a follow-up visit 14 days later and blood pressure will be recorded as per protocols.

Enrollment: 120 patients

Sex: All

Ages: 35+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The inclusion criteria for the study were all newly diagnosed hypertensive patients aged 35 years and above with normal lipid profile

Exclusion criteria

• Patients with a history of dyslipidemias, diabetes mellites, chronic kidney disease, and ischemic heart disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

Amlopdipine only

Active Comparator group

Description:

Newly diagnosed hypertensive patients who will be given only amlodipine.

Treatment:

Drug: Amlodipine 5 MG Oral Tablet

Amlodipine and Atorvastatin

Active Comparator group

Description:

Newly diagnosed hypertensive patients who will be given Amlodipine and Atorvastatin.

Treatment:

Drug: Amlodipine 5 MG / Atorvastatin 10 MG Oral Tablet