ATP Level and Cough Sensitivity to ATP in Subjects With Refractory/Unexplained Chronic Cough

Kefang Lai

Status: Completed

Conditions: Refractory/Unexplained Chronic Cough

Study type: Observational

Funder types: Other

Identifiers

NCT05265871

RCC-ATP

Details and patient eligibility

About

This is a cross-sectional study to investigate ATP level in induced sputum and cough sensitivity to ATP in subjects with refractory/unexplained chronic cough. 60 patients with refractory/unexplained chronic cough and 30 matched healthy controls were recruited. Demographic data, clinical characteristic, cough sacles and medical history records were collected. Cough chanllage(ATP and capsaicin) and ATP measurement in sputum were conducted.The difference of sputum ATP level between patients and control and the correlation between sputum ATP level and cough sensitivity to ATP were analyzed.

Enrollment: 131 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria for patients:

1. ≥18 years old
2. cough as sole symptom lasting ≥6 months
3. cough visual analogue score ≥30mm
4. diagnosed as RCC/UCC according to guidelines

Exclusion criteria for patients:

1. smoking currently or in the past 6 months, or a smoking history of >20 pack-year
2. a forced expiratory volume in 1 second/forced vital capacity ratio <70%;
3. use of inhaled/oral corticosteroid, bronchodilators, anti-allergic medicine, antitussive medicine or anti-reflux treatment in the past 1 week;
4. a history of acute respiratory infection in the past 4 weeks;
5. a history of severe disease (cancer, acute coronary syndrome and so on).

Healthy control aged ≥18 years old are included. Exclusion criteria are as follow:

1. smoking currently or in the past 6 months, or a smoking history of >20 pack-year
2. a forced expiratory volume in 1 second/forced vital capacity ratio <70%
3. a history of acute respiratory infection in the past 4 weeks
4. posstive findings of chest radiography
5. a history of chronic respiratory disease and allergic disease
6. any signs of cough hypersensitivity

Trial design

131 participants in 2 patient groups

refractory/unexplained chronic cough

Description:

Induced sputum test and cough challenge(ATP and capsaicin) were performed.

Healthy control

Description:

Induced sputum test and cough challenge(ATP and capsaicin ) were performed.