Atrasentan Spermatogenesis and Testicular Function

AbbVie

Status and phase

Completed

Phase 2

Conditions

Nephropathy

Diabetes

Treatments

Drug: Atrasentan

Study type

Interventional

Funder types

Industry

Identifiers

NCT02118714

M12-919

2016-000722-19 (EudraCT Number)

Details and patient eligibility

About

This study is being conducted to evaluate the effects of Atrasentan on sperm production and testicular function in male subjects with Type 1 or 2 Diabetes and Nephropathy.

This study included 2 periods: a Treatment Period (up to 26 weeks) followed by an Observational Period (up to an additional 52 weeks).

Enrollment

20 patients

Sex

Male

Ages

30 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Males 30 to 75 years of age
Type 1 or 2 diabetes and receiving treatment with at least one anti-hyperglycemic medication and angiotensin-converting enzyme inhibitors (ACEi)/angiotensin receptor blockers (ARB) (renin-angiotensin system [RAS] inhibitor)
Estimated Glomerular Filtration Rate (eGFR) equal to or greater than 35 mL/min/1.73 m^2 with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) Formula and Urine Albumin-to-Creatinine Ratio (UACR) equal to or greater than 30 and less than 5,000 mg/g creatinine.
Able to provide a semen specimen at the required intervals.
Baseline sperm concentration equal to or greater than 30 million per mL.

Exclusion criteria

Treatment with hormone suppressive agents or cancer chemotherapy within the 6 months prior to the initial screening visit or planned during the study.
History of severe peripheral edema or facial edema unrelated to trauma or history of myxedema in the prior 4 weeks prior to screening.
History of pulmonary hypertension, pulmonary fibrosis or any lung disease requiring oxygen therapy.
Documented diagnosis of heart failure, previous hospitalization for heart failure or current or constellation of symptoms (dyspnea on exertion, pedal edema, orthopnea, paroxysmal nocturnal dyspnea) felt to be compatible with heart failure, that was not explained by other causes, and for which there was a change in medication or other management directed at heart failure.
Currently receiving or has received hormone replacement therapy within 6 months prior to screening.