Atrial Fibrillation and Diabetes Mellitus

Heart and Diabetes Center North-Rhine Westfalia

Status: Enrolling

Conditions: Atrial Fibrillation; Arrhythmias, Cardiac; Cardiovascular Diseases; Heart Diseases; Pathologic Processes

Study type: Observational

Funder types: Other

Identifiers

NCT05873920

HDZ-ER_004_DG

Details and patient eligibility

About

Single center prospective study to analyze the impact of diabetes mellitus on patients' outcome following radiofrequency-guided catheter ablation for atrial fibrillation.

Full description

A total number of 50 patients with diabetes mellitus will undergo radiofrequency-guided catheter ablation for atrial fibrillation. Pre-procedural cardiac MRI will be performed with late-gadolinium enhancement to visualize the individual amount and distribution of fibrosis in the right and left atrium. The relationship between diabetes mellitus and individual atrial arrhythmia substrates as well as patients' outcome following catheter ablation will be analyzed.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing their 1st radiofrequency-guided catheter ablation for atrial fibrillation
• Diabetes mellitus
• Able to understand and willing to sign the Informed Consent Form.
• Age ≥18 years.

Exclusion criteria

• Contraindication for DE-MRI with a full dose of gadolinium-based contrast agent.
• Previous left atrial ablation or surgical procedure
• Women currently pregnant, breastfeeding, or of childbearing age not currently taking or not willing to use a reliable form of contraception
• Mental or physical inability to take part in the study
• Morbid obesity (BMI > 35), or inability to be placed in MRI due to body mass.