Atrial Fibrillation Patients Treated With Catheter Ablation

Chinese Academy of Medical Sciences & Peking Union Medical College

Status

Enrolling

Conditions

Atrial Fibrillation

Atrial Fibrillation Recurrent

Treatments

Procedure: radiofrequency ablation

Study type

Observational

Funder types

Other

Identifiers

NCT05266144

PUMCH-AF

Details and patient eligibility

About

This is a single-center prospective observational cohort study of atrial fibrillation patients treated with radiofrequency ablation.

Full description

The effect of radiofrequency therapy on the life quality and atrial function of atrial fibrillation patients will be assessed, through the multidimensional analysis of baseline clinical data, serological indicators of atrial fibrosis, echocardiography, cardiac magnetic resonance imaging, atrial potential mapping, life quality, and long-term ECG monitoring within 1 week after radiofrequency ablation. A predictive model for atrial fibrillation recurrence after ablation will be established. Based on the cross-sectional analysis of baseline data, the relationship between non-invasive assessment of atrial fibrosis (imaging and serology), atrial electrical activity, and atrial function will be analyzed as well, and atrial fibrillation patients with ventricular fibrosis will be selected for gene sequencing to explore the existence of underlying cardiomyopathy and provide data for further research.

Enrollment

300 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Non-valvular atrial fibrillation, including paroxysmal atrial fibrillation and persistent atrial fibrillation
18-80 years old
The anteroposterior diameter of the left atrium is less than 50mm via TTE
Patient meets the intervention criteria for bilateral pulmonary vein isolation after evaluation by electrophysiological specialists
Patient consents to ablation treatment

Exclusion criteria