Atrial Strain in Septic Shock (ALARMS)

Centre Hospitalier Universitaire, Amiens

Status: Enrolling

Conditions: Critical Care; Left Atrial Strain; Speckle Tracking; Echocardiographic Software; Reproducibility; Transthoracic Echocardiography; Right Atrial Strain; Septic Shock

Study type: Observational

Funder types: Other

Identifiers

NCT06832436

PI2025_843_0034

Details and patient eligibility

About

Septic shock is a critical condition associated with high mortality. Transthoracic echocardiography is widely used to evaluate cardiac function and guide treatment. Left and right atrial strain (LAS and RAS) measured via speckle tracking echocardiography have shown prognostic value in cardiovascular diseases. However, differences exist between echocardiographic software, leading to challenges in result comparability. This study aims to compare LAS and RAS measurements between ECHOPAC and UWS software, evaluate AutoStrain technology, and assess reproducibility across observers. The study is non-interventional and will use retrospective echocardiographic data from patients treated for septic shock. The findings will contribute to improving measurement standardization in critically ill patients.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age: >18 years
• Adult patients admitted to critical care for septic shock (SEPSIS-3 definition)
• TTE performed as part of medical management
• No objection to data usage

Exclusion criteria

• Pregnancy
• Moderate to severe valvular regurgitation/stenosis (>grade 2)
• Ventricular or supraventricular tachyarrhythmia (HR >140 bpm) at the time of TTE
• Poor echogenicity preventing LAS measurement
• Mechanical circulatory support
• Pacemaker dependence
• Patients under guardianship