Atropin and Glucose Stimulated Insulinsecretion and the Cephalic Insulin Response

University Hospital, Gentofte, Copenhagen

Status: Unknown

Conditions: The Focus of This Study is to Evaluete the Significances of the Vagal Cholinerg Nervuos System for the Effect of GLP-1 by Using Atropin Administration.

Treatments: Drug: Placebo; Drug: Atropine

Study type: Interventional

Funder types: Other

Identifiers

NCT01534442

Atropin clamp

Details and patient eligibility

About

The aim of this study is to investigate the role of transmission of vagal cholinerg for the GLP-1 potentiation of the glucose stimulated insulin secretion and the cephalic insulin response by using atropin administration.

The hypothesis is that a great deal of the effects of GLP-1 is mediated via the nervous system and for this reason the investigators will research individuals with an intact nervous supply with and without atropin administration.

Full description

GLP-1 is a importent enterogastron and incretin hormone. Rapid degradation of GLP-1 by dipeptidyl peptidase 4 (DPP-4) suggests that GLP-1 may act locally (through vagal afferents) before being degraded. We aimed to clarify the role of vagal innervation on the incretin effect.

Enrollment: 10 estimated patients

Sex: Male

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age between 18 and 45 years
• normal fasting plasma glucose
• normal hemoglobin
• informed consent

Exclusion criteria

• diabetes mellitus
• body mass index above 30
• inflamatoric bowel disease
• intestinal surgery
• serum creatinine above 250 microM
• ALAT above to times normal value
• treatment with medicine wich cannot be paused for 12 hours
• contraindication for treatment with atropin

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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10 participants in 2 patient groups, including a placebo group

Atropin

Active Comparator group

Description:

Atropin

Treatment:

Drug: Atropine

Placebo

Placebo Comparator group

Description:

Saline

Treatment:

Drug: Placebo