Attention Deficit Hyperactivity Disorder (ADHD) Prediction of Treatment Response

Mass General Brigham

Status

Active, not recruiting

Conditions

Attention Deficit Hyperactivity Disorder

Treatments

Radiation: MRI

Study type

Interventional

Funder types

Other

Identifiers

NCT03153488

2017P000547

Details and patient eligibility

About

This is a 6-month trial in adults to find out if certain neuromarkers can predict individual treatment response to stimulant medications for Attention Deficit Hyperactivity Disorder (ADHD). Males and females, ages 18-45, will complete an MRI scan at MIT prior to beginning medication for ADHD as determined by a treating clinician outside the context of this study.

Enrollment

60 patients

Sex

All

Ages

18 to 55 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Male and female adults ages 18-55
A diagnosis of DSM-V ADHD based on clinical assessment supported by the ADHD module of a structured diagnostic interview
Proficiency in English
Right-handed

Exclusion criteria

Any contraindication for the use of a stimulant medication
Investigator and his/her immediate family (spouse, parent, child, grandparent, or grandchild)
Any contraindications for MRI examination (metallic implants, such as pacemakers, surgical aneurysm clips, or known metal fragments in the body)
Women who are currently pregnant or breastfeeding, as confirmed by a urine pregnancy test
Clinically significant abnormal baseline laboratory values, including systolic and diastolic blood pressure parameters above 140 and 90, respectively and resting heart rate outside 60-100 bpm