Attentional Capture by Real-life Episodic Information (EPICAPTURE)

Civil Hospices of Lyon

Status: Not yet enrolling

Conditions: Attentional Capture; Healthy Volunteers

Treatments: Behavioral: " incongruent vs. congruent contexts " encoding phase and fMRI; Behavioral: Old vs new objects" encoding phase and fMRI

Study type: Interventional

Funder types: Other

Identifiers

NCT06934902

69HCL25_0108

Details and patient eligibility

About

Attention facilitates the allocation of processing resources and the control of behavior among competing stimuli. Current research focuses primarily on attention control networks in the dorsal frontoparietal (DAN) and ventral (VAN) cortex. However, typical laboratory experiments emphasize task-specific processing, neglecting the possible role of memory. Although a few studies have examined the contribution of memory to attention control, they have generally used simple tasks in the laboratory. These tasks are unlikely to produce true traces of episodic memory, which are - by definition - characterized by complex contextual information (what, where, when) and personal relevance. This research will therefore use an innovative protocol based on mobile phone technology to generate episodes in the participants' real lives and then measure the impact of these past personal experiences on attention allocation (by assessing eye movements) and on the activity of the DAN/VAN system (using functional imaging).

The main hypothesis of the study is that knowledge acquired during everyday life contributes to the subsequent allocation of processing resources, via engagement of the DAN/VAN attention systems.

Enrollment: 86 estimated patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Be 18 years old to 40 years old
• Be right-handed
• Do not wear glasses
• Have a mobile-phone compatible with the application, minimum 6rd generation Android operating system, with geo-localization activated and accepted by the user
• Undertake to comply with the instructions and recommendations for MRI examination
• Provide informed written consent to participate in the study

Exclusion criteria

• History of known neurological or psychiatric illness

• Cognitive problems limiting the understanding of instructions

• Recent taking psychotropic drugs (antidepressants, anxiolytics, antipsychotics). The main treatments not authorized during this research are the following: Psychotropic treatments (drugs that can induce changes in perception, sensation, mood, consciousness or behavior). Like what:

• Antipsychotics (valproic acid, amisulpride, aripiprazole, clozapine, cyamemazin, haloperidol, loxapine, olanzapine, risperidone).

• Antidepressants (Amitriptyline, Citalopram, Clomipramine, Duloxetine, Escitalopam, Fluoxetine, Mianserine, Mirtazapine, Nortriptyline, Paroxetine, Sertraline, Venlafaxine).

• Anxyolitics

• Pregnant or breastfeeding women

• Persons deprived of their liberty by a judicial or administrative decision

• Persons admitted to a health or social institution for purposes other than research

• Adults subject to a legal protection measure (guardianship, curatorship)

• Persons not affiliated to a social security scheme or beneficiaries of a similar scheme

• Participation in another research study of the current study

• Contraindication for fMRI scanning

• Participant not agreeing to be informed in the event of the incidental discovery of an anomaly on MRI

  • For visit number 2 :

• Alcohol consumption (> 3 drinks) in the 24h before the experiment

• Alcohol consumption the day of the experiment

• Cafeine consumption 1 hour or less before the experiment

• Drug consumption within the 24h preceding the experiment

• Antimalarial treatment within the 3 days preceding the experiment

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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86 participants in 2 patient groups

Old vs new objects

Experimental group

Description:

The following week after the "Old vs new objects" encoding phase of 3 weeks, participants will have an fMRI. During fMRI, participants will see objects already seen or not seen during the encoding phase.

Treatment:

Behavioral: Old vs new objects" encoding phase and fMRI

incongruent vs. congruent contexts

Experimental group

Description:

The following week after the "incongruent vs. congruent contexts" encoding phase of 3 weeks, participants will have an fMRI. During fMRI, participants will see objects encoding in congruent or incongruent contexts.

Treatment:

Behavioral: " incongruent vs. congruent contexts " encoding phase and fMRI