Attentional Impairment in People With Epilepsy (ETAPE)

Central Hospital, Nancy, France

Status: Not yet enrolling

Conditions: Epilepsy

Treatments: Other: Attentional tasks

Study type: Observational

Funder types: Other

Identifiers

NCT04379128

2019-A02748-49

Details and patient eligibility

About

Epilepsy is one of the most common chronic neurological conditions.It leads to cognitive impairment in 20-50% of patients with a structural form.

In comparison with seizures, these cognitive disorders are a major additional factor in occupational, social and family disability. They are particularly frequent (50%) in temporal epilepsies and preferably concern memory and language skills.

The cognitive consequences of epilepsy are therefore well described in the following areas: episodic memory, language, executive functions.

Concerning attentional abilities, a recent review has highlighted the lack of work in this specific field in order to properly measure the prevalence and nature of attentional disorders in epileptic patients. Indeed, attentional abilities are often mentioned in studies, but attention is a complex domain defined by four modalities: alertness, selective attention, divided attention and sustained attention. No study systematically assesses all of these modalities.

The objective of this study is to evaluate the prevalence and nature of attentional disorders in epileptic patients compared to control subjects.

Enrollment: 272 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Patients:

Inclusion Criteria:

• Patient with epilepsy, according to Fisher et al. (2005).
• Patient with written informed consent
• affiliation to a social security regime is compulsory
• Individuals who have received full information about the organization of the research and have not objected to their participation and the use of their data.
• Patient 18 years of age and older

Normal controls:

Individuals who have received full information about the organization of the research and have not objected to their participation and the use of their data.

• People 18 years of age and older
• People with no neurological and/or psychiatric history

Exclusion Criteria:

for patients: with another progressive neurological condition for all People of full age who are subject to a legal protection measure or who are unable to express their consent People deprived of their liberty by a judicial or administrative decision People who regularly use psychoactive substances (cannabis, alcohol...)

Trial design

272 participants in 2 patient groups

patients with epilepsy

Description:

Attentional tasks : D2-R task and TAP battery (sustained attention, alertness, divided attention) executive task : digit span, incompatibility and flexibility task (TAP battery), verbal fluencies depression score (NDDI-E scale) and anxiety score (GAD-7 scale)

Treatment:

Other: Attentional tasks

Normal controls

Description:

Attentional tasks : D2-R task and TAP battery (sustained attention, alertness, divided attention) executive task : digit span, incompatibility and flexibility task (TAP battery), verbal fluencies depression score (NDDI-E scale) and anxiety score (GAD-7 scale)

Treatment:

Other: Attentional tasks