Attenuation of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation With Single Dose of Dexmedetomidine in Hypertensive Patients.

Assiut University

Status: Completed

Conditions: Stress Response During Laryngoscopy Intubation

Treatments: Drug: sterile saline; Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT03204006

01003060483

Details and patient eligibility

About

Attenuation of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation With Single Dose of Dexmedetomidine in Hypertensive Patients.

Enrollment: 70 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• • Age group 20-60 years
• ASA grade 1 and 2
• control hypertensive patients.

Exclusion criteria

• • Consent not given
• ASA Grade 3 and 4
• history of myocardial ischemia or infarction, or had an abnormal ECG on admission to the hospital
• Patients with cardiovascular, pulmonary, hepatic, and renal disease.
• Patients on B blockers.
• patients with difficult airway; laryngoscopy and intubation time more than 20 s, or requiring more than two attempts will be exclude from the study.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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70 participants in 2 patient groups, including a placebo group

Dexmedetomidine group

Active Comparator group

Description:

35 patients will receive dexmedetomidine 0.5 µg/kg was administered intravenously using a syringe pump over 10 min sterile saline pre-induction of anesthesia.

Treatment:

Drug: Dexmedetomidine

Control group

Placebo Comparator group

Description:

35 patients will receive sterile saline 0.5 µg/kg was administered intravenously using a syringe pump over 10 min pre-induction of anesthesia.

Treatment:

Drug: sterile saline