Attenuation of Pain in Men and Women

University of Wisconsin (UW)

Status: Completed

Conditions: Pain

Treatments: Drug: Naltrexone, then placebo; Drug: Placebo, then Naltrexone

Study type: Interventional

Funder types: Other

Identifiers

NCT01220414

H-2010-0087

Details and patient eligibility

About

The purpose of this study is to examine opioid and endocannabinoid mechanisms of exercise-induced analgesia in men and women.

Enrollment: 60 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: Healthy men and women

Exclusion Criteria:

• current cardiac or other chronic diseases (e.g., cancer, diabetes, hypertension, kidney disease); routine use of prescriptive medications; history of vasovagal response to phlebotomy; an allergy to naltrexone; pregnancy; current smokers; current use of recreational drugs; history of substance abuse

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Men

Active Comparator group

Treatment:

Drug: Placebo, then Naltrexone

Drug: Naltrexone, then placebo

Women

Active Comparator group

Treatment:

Drug: Placebo, then Naltrexone

Drug: Naltrexone, then placebo