Audition After a Lesion and in Migraine. (AuditionPostLesion)

Civil Hospices of Lyon

Status: Completed

Conditions: Migraine Disorders, Brain

Treatments: Other: Neurophysiological tests; Other: Neuropsychological tests

Study type: Interventional

Funder types: Other

Identifiers

NCT02791997

69HCL14_0202

2014-A01289-38 (Other Identifier)

Details and patient eligibility

About

The project studies auditory processing after brain damage (in temporal and/or frontal areas) and in migraine. The auditory processes investigated are attention, short-term memory, sound-induced emotions. To characterize auditory deficits after brain damage or in migraine, neuropsychological assessments are combined with neurophysiological markers (Electro-encephalography: EEG, Magneto-encephalography: MEG, Magnetic Resonance Imaging: MRI).

Enrollment: 262 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age from 18 to 80
• MEG/MRI compatibility
• Motivation to participate efficiently in the study
• No severe hearing loss
• Informed consent to participate in the study
• Affiliation to social security
• For brain-damaged patients : no need for medical assistance; focal temporal and/or frontal lesion; no major cognitive impairment; ability to understand and apply the instructions for neuropsychological testing; testing at least one-month after the event resulting in brain damage; absence of neurological and psychiatric disorders besides the lesion
• For migraine patients: no need for medical assistance; migraine diagnosis; no major cognitive impairment; ability to understand and apply the instructions for neuropsychological testing; absence of neurological and psychiatric disorders besides the migraine
• Healthy participants: absence of neurological and psychiatric disorders

Exclusion criteria

• Age below 18 or above 80
• MRI scanning not possible: artificial cardiac pacemaker, insulin pump, metallic prosthesis, intra-cerebral clip, claustrophobia
• MEG acquisition not possible: large heads, neurostimulator, metal in the head or the body.
• Pregnant or breast-feeding women

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

262 participants in 3 patient groups

Brain-damaged patients

Experimental group

Treatment:

Other: Neuropsychological tests

Other: Neurophysiological tests

Control participants

Experimental group

Treatment:

Other: Neuropsychological tests

Other: Neurophysiological tests

Migraine patients

Experimental group

Treatment:

Other: Neuropsychological tests

Other: Neurophysiological tests