Auditory Deficits in Congenital Amusia (AMUSIE CONGENITALE)
Status
Completed
Conditions
Healthy
Amusia, Congenital
Treatments
Other: Neuropsychological and neurophysiological tests
Other: Experiment 3
Other: Experiment 1
Other: Experiment 4
Other: Experiment 2
Details and patient eligibility
About
The project studies auditory deficits in congenital amusia at the behavioral and neurophysiological levels.
The auditory processes investigated are pitch discrimination, short-term memory, sound-induced emotions. To characterize auditory deficits in the amusic population, neuropsychological assessments are combined with neurophysiological markers (Electro-encephalography: EEG, Magneto-encephalography: MEG, Magnetic Resonance Imaging: MRI).
Enrollment
230 patients
Sex
All
Ages
18 to 70 years old
Volunteers
Accepts Healthy Volunteers
Inclusion criteria
- Aged from 18 to 70 years' old
- French
- Compatibility IRM / MEG (no metal in the body)
- Motivation to participate effectively in the project
- No neurological or psychiatric history
- No severe hearing loss
- Informed consent to participate in the study
- For Amusic participants: participant diagnosed amusic by the MBEA (Montreal Battery of Evaluation of Amusia)
- For Control participants: matched in age, sex, education, music education, laterality, non-amusic (controlled with the MBEA)
Exclusion criteria
- Age below 18 or above 70
- Non-Francophone volunteers.
- MRI scanning not possible: artificial cardiac pacemaker, insulin pump, metallic prosthesis, intra-cerebral clip, claustrophobia
- MEG acquisition not possible: large heads, neurostimulator, metal in the head or the body.
- Pregnant or breast-feeding women
Trial design
Primary purpose
Basic Science
Allocation
Non-Randomized
Interventional model
Parallel Assignment
Masking
None (Open label)
230 participants in 2 patient groups
Amusia
Experimental group
Description:
Since 2006, recruitment of amusia participants has been organized in the Lyon region, and some 20 participants (and their matched controls in terms of age, sex, laterality, musical practice, number of years of study) have already taken part various studies conducted at the CRNL. The recruitment of amusia participants and controls is continued in order to maintain a sufficient number of participants and compensate for the withdrawals within the cohort already constituted (lack of availability, geographical distance, etc.).
Treatment:
Other: Experiment 4
Other: Experiment 2
Other: Experiment 1
Other: Experiment 3
Other: Neuropsychological and neurophysiological tests
Matched controls
Sham Comparator group
Description:
Matched controls of age, sex, laterality, musical practice, number of years of studies.
Treatment:
Other: Experiment 4
Other: Experiment 2
Other: Experiment 1
Other: Experiment 3
Other: Neuropsychological and neurophysiological tests
Trial contacts and locations
1
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Data sourced from clinicaltrials.gov
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