Auditory-motor Coupling in Multiple Sclerosis with Cerebellar Lesions

Hasselt University

Status: Completed

Conditions: Multiple Sclerosis; Cerebral Lesion

Treatments: Other: motor entrainment to auditory cues and music during walking on quality of movement

Study type: Interventional

Funder types: Other

Identifiers

NCT04639401

AMCiMS-001

Details and patient eligibility

About

This study is a case-control observational study, involving persons with multiple sclerosis and healthy controls. The study contains 1 descriptive and 4 experimental sessions. In the descriptive session, participant's clinical motor and cognitive functions are collected. In the first experimental session, participant's beat perception and synchronisation abilities is examined within a finger tapping paradigm. In the following experimental sessions participants synchronsiation abilities is examined during walking paradigms, to music and metronomes, at different tempi and alignment strategies. In the latter three sessions, apart from outcome measures of synchronization the following will be collected as well: spatio-temporal gait parameters, perceived fatigue, perceived motivation and perceived speed of walking.

Enrollment: 8 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• diagnosis of Multiple sclerosis >1 year,
• type of lesions: cerebellar lesions,
• walking speed 0.8-1.2m/s, ability to walk for 6 minutes continuously (canes and rollators are permitted).

Exclusion criteria

• relapse 3 months prior to enrollment,
• cognitive impairment impeding understanding of instructions,
• beat amusia,
• deafness,
• pregnancy

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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8 participants in 2 patient groups, including a placebo group

persons with Multiple Sclerosis

Experimental group

Treatment:

Other: motor entrainment to auditory cues and music during walking on quality of movement

Healthy controls

Placebo Comparator group

Treatment:

Other: motor entrainment to auditory cues and music during walking on quality of movement