Augmented Pulse Pressure Variation to Predict Fluid Responsiveness in Open Laparotomy

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Samsung Medical Center

Status

Completed

Conditions

Abdominal Neoplasms
Gynecologic Neoplasms

Treatments

Other: Fluid loading
Other: Augmented ventilation

Study type

Observational

Funder types

Other

Identifiers

NCT02653469
SMC 2015-06-015

Details and patient eligibility

About

Pulse pressure variation (PPV) is a well-known and widely used dynamic preload indicator based on heart-lung interaction to predict fluid responsiveness. Generally, patients are considered to be fluid-responsive when the PPV value larger than 11-13%. However, several previous researches demonstrated that there is a zone of uncertainty (grey zone) in PPV. To predict fluid-responsiveness accurately in the patients with PPV within grey zone (9-13%), the investigators would evaluate the augmented PPV using augmented ventilation.

Enrollment

38 patients

Sex

All

Ages

20 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Adult patients undergoing elective open laparotomy surgery.

Exclusion criteria

  • Irregular heart beats,
  • cardiac arrhythmia,
  • moderate or severe valvular heart disease,
  • preoperative left ventriular ejection fraction less than 40%,
  • moderate t severe obstructive pulmonary disease,
  • preoperative need of inotropics infusion,
  • preoperative serum Cr > 1.3ml/dl,
  • moderate to severe renal or liver disease,
  • acute lung injury or acute lung problem,
  • coexisting open chest condition,
  • severe bradycardia,
  • patients with spontaneous breathing

Trial design

38 participants in 1 patient group

Augmented ventilation with fluid loading
Description:
This is an observational study and as a diagnostic intervention, subjects in the study would receive mechanical ventilation with augmented tidal volume of 12ml/kg for 2min. Augmented ventilation is performed when the patient's PPV is within grey zone (9-13%). The investigators perform this procedure to every patients and do not assigh this intervention to the subjects of the study. Then, 6ml/kg of ballanced crystalloid loading will be infused to every patient.
Treatment:
Other: Augmented ventilation
Other: Fluid loading

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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