Auricular Acupressure : Improves Oxaliplatin-induced Peripheral Neuropathy

Chang Gung Medical Foundation

Status: Unknown

Conditions: Oxaliplatin-induced Peripheral Neuropathy; Chemotherapy

Treatments: Other: auricular acupressure

Study type: Interventional

Funder types: Other

Identifiers

NCT04751513

202001339B0

Details and patient eligibility

About

Oxaliplatin-induced peripheral neuropathy (OIPN) is a common adverse effect that becomes worse as the drug dose accumulation impacts cancer patients' daily activities and quality of life.The result of this study will determine the immediate effects of the 8-week auricular acupuncture intervention on alleviating the participants' OIPN symptoms and enhancing their quality of life. This study will continue to evaluate the carry-over effects of auricular acupuncture after the chemotherapy course ends.

Full description

Objectives:

Oxaliplatin-induced peripheral neuropathy (OIPN) is a common adverse effect that becomes worse as the drug dose accumulation impacts cancer patients' daily activities and quality of life. This study aims to evaluate the immediate and carry-over effects of auricular acupressure on OIPN symptoms and quality of life for colorectal cancer patients.

Methods :

This randomized trial will recruit 76 participants with colorectal cancer and OIPN from the oncology outpatient department in Taiwan. The control group will receive usual care, whereas the experimental group will receive usual care in addition to auricular acupressure for 8 weeks. Outcomes will be assessed by using the chemotherapy-induced peripheral neuropathy assessment tool, neuropathic pain symptom inventory, pain visual analogue scale, and the European Organization for research and treatment of cancer-quality of life questionnaire-core 30. These assessment tools are used before the intervention, biweekly during the intervention, 2 weeks after the intervention, and one month after the end of the chemotherapy course.

Hypothesis:

Ultimately, the result of this study will determine the immediate effects of the 8-week auricular acupuncture intervention on alleviating the participants' OIPN symptoms and enhancing their quality of life. This study will continue to evaluate the carry-over effects of auricular acupuncture after the chemotherapy course ends.

Enrollment: 76 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Colorectal cancer patients who are above the age of 20 years
• Have experiencing Oxaliplatin induced peripheral neuropathy
• Must be able to communicate
• Willing to fill out the inform consent

Exclusion criteria

• Symptoms of peripheral neuropathy caused by diabetes mellitus
• Symptoms of peripheral neuropathy caused by genetic disease
• Symptoms of peripheral neuropathy caused by spinal cord injury
• Symptoms of peripheral neuropathy caused by alcoholism
• With wounds on ears
• Allergy to latex (the tapes for the auricular acupressure include latex)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

76 participants in 2 patient groups

Experimental group

Experimental group

Description:

The experimental group will receive acupressure on six auricular points.

Treatment:

Other: auricular acupressure

Control group

No Intervention group

Description:

The control group will receive no intervention.