Autogenous Demineralized Dentin Block Graft Versus Autogenous Bone Block Graft for Alveolar Ridge Preservation

Cairo University (CU)

Status: Unknown

Conditions: Alveolar Bone Loss

Treatments: Procedure: Alveolar ridge preservation using autogenous demineralized dentin block graft; Procedure: Alveolar ridge preservation using autogenous bone block graft

Study type: Interventional

Funder types: Other

Identifiers

NCT05347017

perio2022april

Details and patient eligibility

About

The aim of this trial is to compare the effect of autogenous demineralized dentin block graft (ADDBG) versus autogenous bone block graft (ABBG) harvested from maxillary tuberosity on alveolar ridge preservation after extraction of non-restorable single rooted teeth

Full description

Many studies have reported an approximately 50% reduction in alveolar bone both the horizontal and vertical directions over 12 months with more than two-thirds of the reduction occurring in the first three months after extraction. Alveolar ridge preservation is a procedure that attempts to reduce bone dimensional changes that naturally take place following tooth extraction. A broadly recognized approach is the maintenance of bone walls through bone substitute (graft) delivery into the socket, where guided bone regeneration may be a requisite. Autogenous bone graft has osteogenic and osteoinductive effect. however, when attempts were made to use autologous bone chips in socket preservation, they failed to promote healing or stimulate hard tissue formation in the socket. On the other hand, autogenous bone block graft from the tuberosity has shown a feasible, user-friendly, low-cost solution for minimizing soft and hard tissue collapse and dimensional loss following single-rooted tooth extraction.

Moreover, root dentin block is composed of Type I collagen matrix with several osteoinductive non-collagenous proteins such as bone morphogenetic proteins (BMP) and dentin matrix proteins. Geometrically, alveolar bone morphology was maintained by dentin block graft as well as it has micropores (dentinal tubules) of 3-5 μm diameter and macropores of 0.2-0.3 mm diameter for enhancing osteoinductive and osteoconductive functions.

Both demineralized dentin block and autogenous bone block grafts has been utilized for alveolar ridge preservation or augmentation but the superiority of one form over the other is not yet clear

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Non-restorable tooth indicated for extraction
• Single-rooted teeth
• Motivated patients, agree to sign informed consent and complete the follow-up period

Exclusion criteria

• Pregnant females
• active infection at extraction site
• Smokers
• systemic conditions affecting healing (e.g. diabetes, medications as bisphosphonates...)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

Alveolar ridge preservation using autogenous demineralized dentin block graft

Experimental group

Description:

Atraumatic extraction of non-restorable teeth, then the extracted tooth will be prepared and demineralized using HCL acid as demineralized dentin block graft and inserted in the extraction socket

Treatment:

Procedure: Alveolar ridge preservation using autogenous demineralized dentin block graft

Alveolar ridge preservation using autogenous bone block graft

Active Comparator group

Description:

Atraumatic extraction of non-restorable teeth, then autogenous bone block will be harvested from the maxillary tuberosity and reshaped and inserted in the extraction socket

Treatment:

Procedure: Alveolar ridge preservation using autogenous bone block graft