Autogenous Tooth Bone Graft Versus Allogeneic Bone Graft Around Dental Implant in Aesthetic Zone

Tanta University

Status: Invitation-only

Conditions: Hopeless Tooth in Esthetic Zone; Thin Labial Plate of Bone Pre-extraction; Immediate Dental Implants

Treatments: Procedure: immediate implant and grafting with autogenous tooth bone graft; Procedure: immediate implant with allogenic bone graft

Study type: Interventional

Funder types: Other

Identifiers

NCT06773104

diab123

Details and patient eligibility

About

24 patienta with non restorable anterior teeth underwent extraction with immediate implant installation using bone grafts either autogenous tooth bone graft or allogenic bone graft Autogenous tooth bone graft group (study group): 12 patients will have immediate implant placement with autogenous tooth bone graft.

• Allogeneic bone graft group (control group): 12 patients will have immediate implant placement with allogeneic bone graft (demineralized freeze dried bone allograft - cortico cancellous).

Full description

24 patienta with non restorable anterior teeth underwent extraction with immediate implant installation randomized to two groups Autogenous tooth bone graft group (study group): 12 patients will have immediate implant placement with autogenous tooth bone graft.

• Allogeneic bone graft group (control group): 12 patients will have immediate implant placement with allogeneic bone graft (demineralized freeze dried bone allograft - cortico cancellous).

preparation of autogenous tooth bone graft Any restorations, caries, cementum, periodontal ligament and pulp tissue will be removed .The tooth will be grinded using dental bone mill and bone crusher Tooth particles will be sieved to particles size 300 to 1200 microns. The sorted particles will be immersed in 70 % ethanol and 5% Peracetic acid* in a sterile container for 10 minutes to remove any soft tissue remnants, bacteria and smear layer (defatting and sterilization).

Tooth particles will be demineralized using 2% HNO3for 20 minutes to expose the dentine organic matrix.

The bacteria-free particulate dentin will be washed with phosphate buffered saline‡ twice for 5 minutes to restore the PH balance to 7.4. In the same setting, surgical procedure after atraumatic extraction immediate implant willbe inserted according to dimensions taken from CBCT and jumbing gap will be filled with bone graft according to randomization

Enrollment: 24 estimated patients

Sex: All

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Patients with non restorable maxillary anterior teeth need to be extracted.

• Thin labial plate of bone of the tooth to be extracted.
• Patients age above 20years old.
• Good oral hygiene.
• No signs of acute infection or inflammation

Exclusion criteria

• Prior radiation therapy.
• Soft and hard tissue pathology at the operation site.
• Any relevant systemic disease or medication that might compromise bone healing.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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24 participants in 2 patient groups

• Autogenous tooth bone graft group (study group): 12 patients will have immediate implant placement

Experimental group

Description:

• Autogenous tooth bone graft group (study group): 12 patients will have immediate implant placement preparation of autogenous tooth bone graft : Any restorations, caries, cementum, periodontal ligament and pulp tissue will be removed .The tooth will be grinded using dental bone mill and bone crusher (bone graft kit Tooth particles will be sieved to particles size 300 to 1200 microns. The sorted particles will be immersed in 70 % ethanol and 5% Peracetic acid\* in a sterile container for 10 minutes to remove any soft tissue remnants, bacteria and smear layer (defatting and sterilization). Tooth particles will be demineralized using 2% HNO3‡ for 20 minutes to expose the dentine organic matrix. The bacteria-free particulate dentin will be washed with phosphate buffered saline‡ twice for 5 minutes to restore the PH balance to 7.4. In the same setting, after atraumatic extraction immediate implant inserted and juming gap will be filled with autogenous tooth bone graft

Treatment:

Procedure: immediate implant and grafting with autogenous tooth bone graft

• Allogeneic bone graft group (control group

Experimental group

Description:

• Allogeneic bone graft group (control group): 12 patients will have immediate implant placement with allogeneic bone graft (demineralized freeze dried bone allograft - cortico cancellous). after atraumatic extraction and immediate implant insertion jumbing gap will be filled with allogenic bone graft

Treatment:

Procedure: immediate implant with allogenic bone graft