Autologous Adipose Tissue Derived Mesenchymal Stem Cells Transplantation in Patient With Lumbar Intervertebral Disc Degeneration

Biostar Stem Cell Research Institute (R-Bio)

Status

Withdrawn

Conditions

Lumbar Intervertebral Disc Degeneration

Treatments

Procedure: Autologous Adipose Tissue derived MSCs Transplantation

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT01643681

KSC-MSCs-LIDD

Details and patient eligibility

About

The purpose of this study is to investigate the efficacy and safety of autologous transplantation of Adipose Tissue derived Mesenchymal stem cells (MSCs) in patient with lumbar intervertebral disc degeneration.

Sex

All

Ages

19 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Subjects who understand and sign the consent form for this study
Age :19-70, males and females
Have chronic low back pain for at least 1 year
Have failed 1 year of non-operative low back pain management
Have degenerated intervertebral disc on T2-weighted MR images
confirmed by positive discography
Have significant lumbar instability at degenerated intervertebral disc

Exclusion criteria

Have significant lumbar herniated intervertebral disc
Women who are pregnant or breast feeding or planning to become pregnant during the study
History or current evidence of alcohol or drug abuse or is a recreational user of illicit drugs or prescription medications
Serious pre-existing medical conditions like Cardiovascular Diseases, Renal Diseases, Liver Diseases, Endocrine Diseases, Cancer and Diabetes Mellitus
Participation in another clinical trial or treatment with a different investigational product within 30 days prior to inclusion in the study
Other pathologic conditions or circumstances that difficult participation in the study according to medical criteria