Autologous Blood Transfusion After Local Infiltration

Northern Orthopaedic Division, Denmark

Status: Completed

Conditions: Total Hip Arthroplasty; Total Knee Arthroplasty

Treatments: Drug: Autologous blood transfusion with ropivacaine

Study type: Observational

Funder types: Other

Identifiers

NCT01576263

N-20090061

Details and patient eligibility

About

Total knee and hip arthroplasty for osteoarthritis is performed on still broader indications even in elderly patients with previous or current medical conditions. Especially comorbidity like cardiovascular diseases and conditions with increased risk of bleeding or previous thrombo-embolic events are major challenges.

To facilitate safe use of ropivacaine as an analgesic, information on the concentrations levels after autologous blood transfusion following local infiltration analgesia is very crucial. However, very limited data are available. To verify the safety of autologous blood transfusion, ropivacaine concentrations were studied in 52 patients undergoing either total knee arthroplasty or total hip arthroplasty.

Enrollment: 52 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis for hip arthroplasty
• Clinical diagnosis for knee arthroplasty

Exclusion criteria

• Patients < 18 years
• Lack of informed consent
• Inability to read/understand Danish
• Bilateral diagnosis
• Cancer diagnosis

Trial design

52 participants in 2 patient groups

Total knee arthroplasty

Description:

25 consecutive patients diagnosed for total knee arthroplasty.

Treatment:

Drug: Autologous blood transfusion with ropivacaine

Drug: Autologous blood transfusion with ropivacaine

Total hip arthroplasty

Description:

27 patients diagnosed for total hip arthroplasty.

Treatment:

Drug: Autologous blood transfusion with ropivacaine

Drug: Autologous blood transfusion with ropivacaine