Autologous Bone Marrow Stem Cells Transplantation in Patients With Temporal Lobe Epilepsy

Instituto do Cerebro de Brasilia

Status and phase: Completed; Phase 1

Conditions: Epilepsy

Treatments: Procedure: Stem cell transplantation

Study type: Interventional

Funder types: Other

Identifiers

NCT00916266

Stem cells in Epilepsy

Details and patient eligibility

About

This research investigates the use of autologous bone marrow stem cells for the treatment of medically refractory temporal lobe epilepsy patients.

Full description

The aim of this study is to evaluate autologous bone marrow stem cells transplantation as a safe and potentially beneficial treatment for patients with temporal lobe refractory epilepsy. We are mainly evaluating seizure frequency, hippocampal volume an cognitive performance

Enrollment: 20 patients

Sex: All

Ages: 18 to 64 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• temporal lobe medically refractory epilepsy patients with hippocampal atrophy

Exclusion criteria

• under 18 or over 65 years old patients
• previous neurological surgery
• other neurodegenerative diseases

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

stem cell transplantation

Experimental group

Description:

Patients with refractory temporal lobe epilepsy that are transplanted with autologous bone marrow stem cells in order to provide seizure control.

Treatment:

Procedure: Stem cell transplantation