Autologous Conditioned Plasma (ACP) for Patients With Plantar Fasciitis

University of Western Ontario, Canada

Status

Unknown

Conditions

Chronic Plantar Fasciitis

Treatments

Procedure: ACP

Drug: Corticosteroid (celestone) injection

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT01614223

FKSCM 2010 -1

Details and patient eligibility

About

Plantar fasciitis presents clinically as pain in the inner heal, which is the result of degeneration of the plantar fascia, an arch supporting ligament of the foot. It manifests predominantly in those subjected to sustained weight bearing or repetitive pounding activities. Plantar fasciitis is the most common cause of inferior foot pain. Although most cases resolving within 6 months, traditional treatment regiments such as orthotics and physiotherapy are occasionally unsuccessful in treating this limitation leading to chronic symptoms (Neufeld & Cerrato, 2008; Rompe, 2009; Roxas, 2005).

Platelets are central players in clotting, inflammation and the wound healing response. Research has shown the potential of platelet rich plasma to accelerate wound healing in a variety of conditions including maxillo-fascial and plastic surgery, chronic wound healing and orthopaedics. Autologous Conditioned Plasma (ACP) is a novel treatment that may accelerate the healing of injured tissue. Treatment with ACP involves taking a blood sample from the patient, isolating the platelets and injecting them back into that patient at the injury site

Enrollment

140 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Painful inner heel pain for longer than three months
at least six weeks since last corticosteroid injection
four weeks since the last anaesthetic injection, iontophoresis, ultrasound and electromyostimulation
one week since the last NSAIDs taken
two days since the last analgesic, heat, ice, message, stretching, or modification of night splints and orthosis.
scores greater or equal to 5 on the VAS PFPD scale
scores greater or equal 30 on the AOFAS scale
scores of greater or equal to 5 on the VAS PFPD scale and 30 on the AOFAS scale

Exclusion criteria

tendon rupture
neurological or vascular insufficiencies in the painful heel
bilateral heel pain
Paget's disease or calcaneal fat pad atrophy
osteomyelitis, fracture of the calcaneus, ankle inflammation
recent infection in the treatment area, history of rheumatic diseases
collagenosis or metabolic disorders
immunosuppressive therapy or coagulation disturbance and/or therapy, long-term treatment with corticosteroids
previous heel surgery
malignant disease, diabetes mellitus, severe cardiac or respiratory disease, significant abnormalities in hepatic function
participation in another clinical study at the same time.