Autologous Conditioned Plasma (ACP) Intra-articular (IA) Injections for Knee Osteoarthritis (OA)

Arthrex

Status

Completed

Conditions

Osteoarthritis

Treatments

Other: Placebo

Device: ACP

Study type

Interventional

Funder types

Industry

Identifiers

NCT02713542

004

Details and patient eligibility

About

This study is primarily investigating the effectiveness of Autologous Conditioned Plasma (ACP) Intra-articular (IA) in patients with Osteoarthritis (OA) in the knee.

Full description

This study is a prospective, multi center randomized double blind, two arm study.

90 subjects will be randomized to receive injections of either Autologous Conditioned Plasma Intra-articular or the control.

Enrollment

90 patients

Sex

All

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

The subject is 18 to 70 years of age.
The subject presents with complaints of continued pain of primary knee for at least 6 weeks.
The subject has documented radiographs evidence of Osteoarthritis (OA) in the tibio-femoral or patella-femoral compartment of the target knee (Kellgren-Lawrence Grades II-III), using radiographs performed within 24 weeks of screening.
The subject has a WOMAC pain score of at least 8 out of 20 and at least moderate pain (a score of 2) for at least 2 questions on activities

Exclusion criteria

Grade I and IV on the knee Kellgren-Lawrence grading scale
Subject has clinically 3+ effusion of the target knee (stroke test grading system).
Subject has significant (> 10⁰) valgus or varus deformities as evidenced by standard of care X-ray.
Subject has had systemic or IA injection of corticosteroids in any joint within three months prior to screening.
Viscosupplementation in any joint in the past six months.
Subject has an increased risk for post- procedure bleeding (e.g., bleeding disorder or taking anticoagulants except low-dose aspirin).
Subject had prior open surgery on the target knee within 12 months or knee arthroscopy within 6 months
Subject has inflammatory disease of either knee other than OA.
Subject with underlying medical conditions that could interfere with the evaluation of the outcome.
Subject with positive pregnancy test, or breast feeding.
Subject with plans to participate in other clinical trial involving medical or surgical intervention in the next 12 months.
Subject with any condition (including cognitive impairment) that, in the opinion of the investigator, might interfere with the evaluation of the study objectives.
Subject has rheumatoid arthritis or gout
Subject has a history of or a current infection at the affected joint.
Subject with plans to undergo any elective orthopedic surgery in the next 12 months.
Subject requires pain management therapy (with the exception of acetaminophen) not related to the target knee.