Autologous Fibroblast Grafts in Facial Skin Regeneration

Federal University of São Paulo

Status

Unknown

Conditions

Skin Aging

Treatments

Procedure: autologous fibroblasts grafts

Study type

Interventional

Funder types

Other

Identifiers

NCT01490554

CEP UNIFESP-1787/07

Details and patient eligibility

About

The purpose of this study is to evaluate the presence of skin changes after grafting of autologous fibroblasts by means of biophysical, histological, immunohistological, gene expression, glycosaminoglycan, and sensitivity analyses.

Full description

Analytical prospective autocontrolled study

Enrollment

20 patients

Sex

Female

Ages

50 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Women, aged between 50 to 70 years with facial wrinkles (rhytides),
Fitzpatrick III skin type, and
Who had reached menopause at least 3 years before entering the study were eligible for participation.

Exclusion criteria

Women with uncontrolled comorbid conditions,
Smokers,
Alcohol and corticosteroid users,
Who had undergone chemical peeling or skin filling in the face or neck at least 12 months prior to the study,
Who had a keloid scar,
Who scored below 18 on the Mini-Mental State Examination,
Who had any psychiatric disorder or those undergoing orthodontic treatment were excluded from the study.