Autologous Platelet Enriched Gel Versus Metalloproteinase Inhibitor in the Healing of Chronic Lower Leg Ulcers

Ghent University Hospital (UZ)

Status: Completed

Conditions: Chronic Lower Leg Ulcer

Treatments: Other: Autologous Platelet Enriched Gel; Other: Metalloproteinase Inhibitor

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00658983

2008/049

Details and patient eligibility

About

Compare Autologous Platelet Enriched Gel versus Metalloproteinase Inhibitor in the healing of chronic lower leg ulcers.

Enrollment: 18 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 year or older
• A non-healing chronic lower leg ulcer
• Platelet ranges of 150000 per ml circulating blood

Exclusion criteria

• Presence of a tumor or metastatic disease
• Hypersensitive to collagen regenerated cellulose
• Hemodynamic unstable patient
• Hypercoagulability
• Heart decompensation or angina pectoris

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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18 participants in 2 patient groups

1

Experimental group

Description:

Autologous Platelet Enriched Gel

Treatment:

Other: Autologous Platelet Enriched Gel

2

Active Comparator group

Description:

Metalloproteinase Inhibitor (Promogran)

Treatment:

Other: Metalloproteinase Inhibitor