Autologous Platelet-Rich Plasma Cream for Photoaging and Chronological Skin Aging

Acibadem University

Status and phase: Unknown; Phase 2; Phase 1

Conditions: Photoaging of Skin; Chronological Aging of Skin

Treatments: Biological: Placebo - Sterile Water Cream; Biological: Platelet Rich Plasma Cream

Study type: Interventional

Funder types: Other

Identifiers

NCT02303496

PRP-CREAM-1

Details and patient eligibility

About

Human skin undergoes some morphological changes with the effects of chronological aging and photoaging, these are especially remarkable in the facial skin. Changes in pigmentation, sallowness, deep wrinkling, laxity and elastosis are the main changes seen in photoaging and chronologic aging of skin. With the increasing demand, it needs to provide new approach for the prevention and treatment of these morphological changes.

Fibroblasts have a key role on skin aging. It is known that platelet rich plasma activates the fibroblasts and increases the synthesis of collagen and other type of matrix components. Because of these specialities, platelet rich plasma is thought to be effective on skin aging.

Full description

Clinical evaluation of the patients will be done for five times during 3 months. 0th day (Basal), 7th day, 15th day, 45th day and 105th day.

Enrollment: 20 estimated patients

Sex: Female

Ages: 35 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• The patient has periorbital wrinkles with Glogau Scale 3 or more

Exclusion criteria

• Patients with precancerous lesions
• Patients with inflammatory skin disease like rosacea, psoriasis, seborrheic eczema
• Patients with connective tissue disease like lupus erythematosus
• Patients have a cosmetic intervention to their face, like chemical peel, infrared, radio frequency, laser, fillers or botulinum toxin injections in last 6 months
• Patients who use an anti aging cream containing retinoic acid, vitamin C and peptides in last 3 months
• Pregnant or lactating females

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Double Blind

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20 participants in 2 patient groups

PRP Cream Application

Experimental group

Description:

Application of Cream Containing Platelet Rich Plasma and Oleaginous Base

Treatment:

Biological: Platelet Rich Plasma Cream

SW Cream Application - Placebo

Active Comparator group

Description:

Application of Cream Containing Sterile Water and Oleaginous Base

Treatment:

Biological: Placebo - Sterile Water Cream