Autologous Platelet Rich Plasma on Low Back Pain

Naval Military Medical University (Second Military Medical University)

Status: Unknown

Conditions: Low Back Pain

Treatments: Other: PRP Treatment(P); Drug: Medication Treatment(Loxoprofen Sodium tablets,M)

Study type: Interventional

Funder types: Other

Identifiers

NCT02983747

201540379

Details and patient eligibility

About

The purpose of this study is to evaluate the effectiveness of autologous platelet-rich plasma (PRP) injection therapy for low back pain patients. Our hypothesis is that PRP will reduce the pain feeling and benefit for restore of the intervertebral disk.

Enrollment: 112 estimated patients

Sex: Male

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic low back pain more than 2months
• Visual analog scale score more than 4
• Positive X-ray, MRI or CT scan findings
• Pfirrmann grading I-III
• Well understanding and communication ability

Exclusion criteria

• History of allergy
• Hemorrhagic trend or use of anticoagulant therapy
• Mental diseases
• Active infection or recent infectious diseases within 3 months
• Local skin infection near the puncture location
• Severe lumbar spinal stenosis, lumbar spondylolisthesis, ossification of posterior longitudinal
• Ligament and lumbar disc herniation（more than 5mm）
• Immunologic diseases
• Tumors
• Metastatic disease
• Recent surgery less than 3 months)
• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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112 participants in 2 patient groups

PRP Treatment(P)

Experimental group

Description:

PRP intra-disk injection therapy combined with NSAIDs medication (Loxoprofen Sodium tablets).

Treatment:

Drug: Medication Treatment(Loxoprofen Sodium tablets,M)

Other: PRP Treatment(P)

Medication Treatment(M)

Active Comparator group

Description:

NSAIDs medication(Loxoprofen Sodium tablets) therapy only.

Treatment:

Drug: Medication Treatment(Loxoprofen Sodium tablets,M)