Automated 3D (SonoAVC) Versus 2D Ovarian Follicles Assessment in IVF Cycles: a Randomized Controlled Trial

Clalit Health Services

Status: Completed

Conditions: Infertility

Treatments: Other: 3D follicles assessment; Other: 2D follicles assessment

Study type: Interventional

Funder types: Other

Identifiers

NCT01723267

rmcavibh-1

Details and patient eligibility

About

Accurate assessment of the size of follicles is important in IVF treatment.Timing of oocyte maturation and subsequent egg collection is largely based on follicle size. An accurate assessment of follicle size and appropriate timing of HCG result in retrieval of more mature oocytes, improved fertilization and higher pregnancy rates. in 3D technology- fter the capturing of a 3D image of an ovary, SonoAVC automatically analyzes the volume dataset, identifies the boundaries of hypoechoic follicles, and provides estimates of their absolute dimensions. These measurements include the largest diameters in three orthogonal planes, the mean follicular diameter (MFD), the volume of the follicle, and the volume-based diameter (d(V)) of the follicle. In the current study the investigators aim to evaluate the use of this automated technique of follicle measurement vs. standard 2D technology on the timing of oocyte maturation and subsequent oocyte retrieval. The investigators speculate that 3D assessment will increase the rate of mature oocyte collection, and eventually will improve other treatment outcomes such as fertilization rate.

Full description

Not desired

Enrollment: 54 patients

Sex: Female

Ages: 18 to 39 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age:18-39, cycle number 1-4

Exclusion criteria

• PCOS
• Endometriosis
• Poor ovarian response
• TESA sperm

Trial design

54 participants in 2 patient groups

3D follicles assessment

Active Comparator group

Description:

During IVF treatment all ultrasound examinations will use 3D- SonoAVC technology. Timing of hCG injection and oocyte collection will be based on follicle volume and 3D-volume based diameter.

Treatment:

Other: 3D follicles assessment

2D follicles assessment

Active Comparator group

Description:

During IVF treatment all ultrasound examinations will use standard 2D ultrasound. Timing of hCG injection and oocyte collection will be based on follicle diameter.

Treatment:

Other: 2D follicles assessment