Automated Breast Radiation Therapy Using an MR-Guided Process

University Health Network, Toronto

Status

Active, not recruiting

Conditions

Breast Cancer

Treatments

Other: IMRT + CT + MR scan

Study type

Interventional

Funder types

Other

Identifiers

NCT01999062

UHN REB 12-5181-CE

Details and patient eligibility

About

In the proposed research study, we are investigating the feasibility of integrating automated planning tools to MR images acquired using a novel MR-guided linac, for on-line adaptive radiation treatment. However, these on-line automation tools require further technical refinement and clinical validation. The goal of this research proposal is to develop an on-line MR-guided radiation therapy process for adapting breast IMRT treatment. Such an approach will provide early stage breast cancer patients timely access to high-quality adaptive treatments without exposure to additional ionizing radiation.

Enrollment

160 estimated patients

Sex

Female

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients who will receive standard two-field tangential whole breast radiation therapy with dose prescription of 4240 cGy in 16 fractions, 5000 cGy in 25 fractions or 4000 cGy in 16 fractions.
Female patients with any stage of breast cancer.
Patients with prior treatment such as surgery or chemotherapy for any type of cancer.
Able to provide a written informed consent.
≥ 18 years of age.

Exclusion criteria

Patients who will not receive 4240 cGy in 16 fractions, 5000 cGy in 25 fractions, or 4000 cGy in 16 fractions
Males.
Patients who received partial breast radiation and not the standard dose.
Patients who are unable to provide informed consent.
< 18 years of age.