Automated Imaging Differentiation of Parkinsonism (AIDP)

University of Florida

Status: Active, not recruiting

Conditions: Parkinson Disease; Multiple System Atrophy, Parkinson Variant; Progressive Supranuclear Palsy

Treatments: Diagnostic Test: AIDP

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT05913687

IRB202002350

PRO00028349 (Other Identifier)

5U01NS119562 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The purpose of this study is to test the performance of the AID-P across 21 sites in the Parkinson Study Group. Each site will perform imaging, clinical scales, diagnosis, and will upload the data to the web-based software tool. The clinical diagnosis will be blinded to the diagnostic algorithm and the imaging diagnosis will be compared to the movement disorders trained neurologist diagnosis.

Enrollment: 315 estimated patients

Sex: All

Ages: 40 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Parkinson's disease diagnosis within 5-9 years of baseline date
• MSAp diagnosis
• PSP diagnosis

Exclusion criteria

• metal implants in the body that preclude an MRI (pacemaker, metallic clip, neurostimulator, etc)
• claustrophobia
• pregnancy

Trial design

315 participants in 3 patient groups

Parkinson's disease

Description:

Clinically diagnosed Parkinson's disease

Treatment:

Diagnostic Test: AIDP

Multiple System Atrophy, Parkinsonian variant

Description:

Clinically diagnosed Multiple System Atrophy, Parkinsonian variant

Treatment:

Diagnostic Test: AIDP

Progressive Supranuclear Palsy

Description:

Clinically diagnosed Progressive Supranuclear Palsy

Treatment:

Diagnostic Test: AIDP