Autonomic Adaptations to Hydration and Brain Functioning

S

Swansea University

Status

Completed

Conditions

Hydration

Treatments

Other: No drink
Biological: Water

Study type

Interventional

Funder types

Other

Identifiers

NCT03525470
DB-0123-Hydration

Details and patient eligibility

About

The influence of relatively small decreases in hydration status have been little studied. On two occasions subjects will be allowed to lose about 0,5% of their body weight and one occasion 300ml of water will be consumed. Functional MRI will be used to monitor brain functioning when performing a mental arithmetic task. Heart rate variability will be monitored and related to differences in brain functioning when water has and has not been drunk

Full description

On two mornings twelve male participants will be exposed to a temperature of 30oC for four hours and either drink or not drink two 150ml glasses of water during that time. The subjects the participate in an fMRI protocol during which they complete a modified version of the Paced Auditory Serial Addition Test (PASAT): a challenging arithmetic task designed to elicit autonomic arousal. Throughout the morning subjects will their heart rate variability (HRV) monitored. At periodic intervals subjects will rate their thirst and mood by visual analogue scales and at the end of the PASAT task they rate its difficulty. Changes in body temperature and fluid loss (perspiration and urine) and urine osmolality will be monitored.

Enrollment

12 patients

Sex

Male

Ages

20 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

  • Self declared as healthy and not taking any medication

Exclusion Criteria:

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

12 participants in 2 patient groups

Water
Experimental group
Description:
Subjects consumed water
Treatment:
Biological: Water
No water
Experimental group
Description:
Subjects did not consume water
Treatment:
Other: No drink

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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