Autonomic and Cytokines Profiles of Patients With Ulcerative Proctitis

Johns Hopkins University

Status: Terminated

Conditions: Inflammatory Bowel Diseases

Treatments: Other: ECG recording, inflammatory cytokines, microbiota, ulcerative colitis disease activity index

Study type: Observational

Funder types: Other

Identifiers

NCT03259659

IRB00095405

Details and patient eligibility

About

1. To prove that patients with ulcerative proctitis and proctosigmoiditis have impaired autonomic functions, i.e. increased sympathetic activity and/or reduced vagal tone.
2. To demonstrate inflammatory cytokine imbalance, i.e., increased pro-inflammatory cytokines. Presence of these abnormalities would make patients with ulcerative proctitis and proctosigmoiditis good candidates for future sacral nerve stimulation therapy.

Enrollment: 20 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• No any systemic diseases;
• no proctitis or proctosigmoiditis;
• no history of gastrointestinal surgery;
• no symptoms of diarrhea or fecal urgency during the past 2 weeks;
• not taking any medications except contraceptives during the past 2 weeks;
• age 18-65.

Exclusion criteria

• None.

Trial design

20 participants in 2 patient groups

irritable bowel disease patient

Description:

Patients with ulcerative proctitis and proctosigmoiditis who meet the inclusion criteria, they will have ECG recording, inflammatory cytokines, microbiota, ulcerative colitis disease activity index.

Treatment:

Other: ECG recording, inflammatory cytokines, microbiota, ulcerative colitis disease activity index

healthy control

Description:

Healthy participates who meet the inclusion criteria, they will have ECG recording, inflammatory cytokines, microbiota, ulcerative colitis disease activity index.

Treatment:

Other: ECG recording, inflammatory cytokines, microbiota, ulcerative colitis disease activity index