Autonomic Dysfunction in Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis : A Comparative Study (English Title)

Mohamed Moshref abd alsattar

Status: Not yet enrolling

Conditions: NMO and MS

Treatments: Diagnostic Test: Bedside cardiovascular reflex tests

Study type: Observational

Funder types: Other

Identifiers

NCT07273292

Autonomics in NMO and MS

Details and patient eligibility

About

To compare the frequency and patterns of autonomic dysfunction in patients with NMOSD and MS, and to investigate its correlations with clinical disability, radiological findings, fatigue, and quality of life parameters

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients (≥18 years , both sexes.
• Confirmed diagnosis of NMOSD according to the 2015 International Consensus Criteria.
• Confirmed diagnosis of RRMS according to the 2024 McDonald diagnostic criteria.

Exclusion criteria

• Comorbidities affecting autonomic function (e.g., diabetes, Parkinsonism).
• Medications known to interfere with autonomic testing.
• Cognitive impairment precluding questionnaire completion.