Autonomic Dysfunction in Resistant Hypertension (RH)

University of Campinas, Brazil

Status: Completed

Conditions: Hypertension, Resistant to Conventional Therapy

Study type: Observational

Funder types: Other

Identifiers

NCT01833429

907/2011

Details and patient eligibility

About

The contribution of this study is the unedited evaluation of the circadian autonomic profiles of resistant hypertension with and without white-coat response.

Full description

All patients were submitted to office blood pressure measurement, Ambulatory blood pressure monitoring and 24-hour Holter monitoring.

Baseline blood samples for the measurement of glycemia (mg/dL), total cholesterol (mg/dL), LDL cholesterol (mg/dL), triglycerides (mg/dL), creatinine (mg/dL), serum uric acid, serum sodium, serum potassium, plasma aldosterone concentration (PAC) and plasma renin activity (PRA) were collected at 08:00 after overnight fasting.

Enrollment: 44 patients

Sex: All

Ages: 30 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• resistant hypertensive patients

Exclusion criteria

• White-coat hypertension
• obstructive sleep apnea

Trial design

44 participants in 1 patient group

Resistant Hypertension

Description:

The current definition of resistant hypertension (RH) includes both patients whose blood pressure (BP) is uncontrolled on three or more medications and those whose BP is controlled when using four or more antihypertensive medications