Autonomic Nervous Activity in Women With Gestational Diabetes

University of Helsinki

Status: Completed

Conditions: Gestational Diabetes

Study type: Observational

Funder types: Other

Identifiers

NCT00867022

GESTSYMPIS

Details and patient eligibility

About

Through complex hormonal pathways, insulin resistance can lead to the activation of the sympathetic nervous system, and vice versa. Schobel et al. showed that in PE patients, mus-cle sympathetic nerve activity (MSNA) is increased compared with normotensive pregnant and non-pregnant women. Studies assessing heart-rate variability and plasma noradrenalin concentrations also suggest increased sympathetic activity in PE. It has been hypothesized that sympathetic over-activity is a precursor of PE, normally compensated for by vasodilating mechanisms, but resulting in PE when the mechanisms fail. In addition to sympathetic activity, various markers of inflamma-tion are also associated with reduced insulin sensitivity, suggesting that chronic sub-clinical inflamma-tion could be part of the insulin resistance syndrome. The role of sympathetic over-activity and inflammatory markers in gestational diabetes has not been investigated

Enrollment: 80 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of gestational diabetes (OGTT) with or without BP > 140/90.
• Pregnant control with normal OGTT-

Exclusion criteria

• Smoking
• Uncontrolled hypertension
• Diabetes
• Medication affecting sympathetic activity

Trial design

80 participants in 4 patient groups

1

Description:

Women with gestational diabetes

2

Description:

Pregnant women without gestational daibetes

3

Description:

Women with gestational diabetes and hypertension

4

Description:

Non pregnant women