Autonomic Nervous Activity in Women With Gestational Diabetes

U

University of Helsinki

Status

Completed

Conditions

Gestational Diabetes

Study type

Observational

Funder types

Other

Identifiers

NCT00867022
GESTSYMPIS

Details and patient eligibility

About

Through complex hormonal pathways, insulin resistance can lead to the activation of the sympathetic nervous system, and vice versa. Schobel et al. showed that in PE patients, mus-cle sympathetic nerve activity (MSNA) is increased compared with normotensive pregnant and non-pregnant women. Studies assessing heart-rate variability and plasma noradrenalin concentrations also suggest increased sympathetic activity in PE. It has been hypothesized that sympathetic over-activity is a precursor of PE, normally compensated for by vasodilating mechanisms, but resulting in PE when the mechanisms fail. In addition to sympathetic activity, various markers of inflamma-tion are also associated with reduced insulin sensitivity, suggesting that chronic sub-clinical inflamma-tion could be part of the insulin resistance syndrome. The role of sympathetic over-activity and inflammatory markers in gestational diabetes has not been investigated

Enrollment

80 patients

Sex

Female

Ages

18 to 45 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Clinical diagnosis of gestational diabetes (OGTT) with or without BP > 140/90.
  • Pregnant control with normal OGTT-

Exclusion criteria

  • Smoking
  • Uncontrolled hypertension
  • Diabetes
  • Medication affecting sympathetic activity

Trial design

80 participants in 4 patient groups

1
Description:
Women with gestational diabetes
2
Description:
Pregnant women without gestational daibetes
3
Description:
Women with gestational diabetes and hypertension
4
Description:
Non pregnant women

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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