Autonomic Nervous System Activity, Aging and Sleep Apnea/Hypopnea (SYNAPSE)

Centre Hospitalier Universitaire de Saint Etienne

Status: Active, not recruiting

Conditions: Healthy

Treatments: Other: Sleep apnea/hypopnea detection

Study type: Observational

Funder types: Other

Identifiers

NCT00766584

DGS 2003/0069

0201085

Details and patient eligibility

About

The regulatory effects of the autonomic nervous system (ANS) concern almost all organs which permanently feed information back to this global biological vigilance system controlling allostasis. Heart rate fluctuations are highly dependent on ANS control, making the heart one of the best indicators of ANS activity.

Low ANS activity level is associated with severe cardiac and cerebral events, as well as to death from any cause in the general population. It is even associated with sleep apnea/hypopnea.

Full description

The main goal of this SYNAPSE study is to evaluate, on a selected prospective cohort of subjects aged 67 years upon study entry, the incidence of sleep apnea/hypopnea and the prognostic values of ANS activity levels measured at preset times and of cardiovascular or cerebrovascular events.

Enrollment: 852 patients

Sex: All

Ages: 67 to 68 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• informed consent signed
• to participate in the PROOF study

Exclusion criteria

• prior myocardiac infarction
• prior stroke
• hearth failure
• atrial fibrillation
• insulin-treated diabetes mellitus
• cardiac pacemaker
• disease limiting life expectancy to < 5 years
• contraindication to brain MRI
• living in an institution
• respiratory failure with oxygenotherapy
• sleep-related breathing disorders known and treated

Trial design

852 participants in 1 patient group

PROOF cohort

Description:

This cohort is the same than the PROOF study (NCT00759304). Subjects were recruited amongst the inhabitants of the city of Saint-Etienne, France, and were eligible if aged 65 at the inclusion date in the PROOF study

Treatment:

Other: Sleep apnea/hypopnea detection