Autonomic Regulation in Prader-Willi Syndrome

Buddhist Tzu Chi Medical Foundation

Status: Unknown

Conditions: Autonomic Dysfunction

Treatments: Diagnostic Test: Polysomnography; Other: Continuous positive airway pressure; Diagnostic Test: Multiple sleep latency test

Study type: Observational

Funder types: Other

Identifiers

NCT04118816

08-XD-008

Details and patient eligibility

About

To evaluate autonomic regulation in patients with Prader-Willi syndrome with sleep-disordered breathing.

Full description

To evaluate the relationship between narcolepsy and sleep-disordered breathing, the natural course of untreated or treated sleep-disordered breathing and its impacts on autonomic regulation in patients with Prader-Willi syndrome with sleep-disordered breathing.

Enrollment: 120 estimated patients

Sex: All

Ages: 7 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 7-75 y/o Prader-Willi syndrome patients or healthy subjects
• can perform polysomnography, multiple sleep latency test
• orthostatic methods for autonomic function test
• can perform pulmonary function test.

Exclusion criteria

• less than y/o, or larger then 75 y/o
• cannot perform polysomnography, multiple sleep latency test
• cannot orthostatic methods for autonomic function test
• cannot perform pulmonary function test
• use of sedatives or drugs affecting autonomic function

Trial design

120 participants in 2 patient groups

Control

Description:

Healthy subjects, 7-75 y/o

Treatment:

Diagnostic Test: Multiple sleep latency test

Diagnostic Test: Polysomnography

Study

Description:

7-75 y/o, diagnosed with Prader-Willi syndrome.

Treatment:

Diagnostic Test: Multiple sleep latency test

Other: Continuous positive airway pressure

Diagnostic Test: Polysomnography