Autophagy/Apoptosis Balance During Pregnancy (GROSSAUTOP)

Centre Hospitalier Universitaire de Nīmes

Status: Completed

Conditions: Pregnancy Related

Treatments: Other: Blood test

Study type: Observational

Funder types: Other

Identifiers

NCT04443660

NIMAO/2019-01/SB-01

Details and patient eligibility

About

The object of this study is to assess the intra- and inter-individual variability of apoptosis and autophagy activities in women during pregnancy: 1 / in women with a normal pregnancy and 2 / in pregnant women particularly at risk of complications.

The study investigators hypothesize that there would be an intra-trophoblastic dialogue between the mechanisms of autophagy and apoptosis, the promotion of one partially inhibiting the other. The increase in trophoblastic autophagy during pregnancy could thus constitute an anti-apoptosis defense phenomenon, the exhaustion of which would lead to cellular apoptosis and to pathogenic consequences when it devastates the syncytiotrophoblast.

Enrollment: 97 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients followed at the CHU Nimes prior to 33 weeks gestation who give birth at the hospital
• The patient must have given their free and informed consent and signed the consent form
• The patient must be a member or beneficiary of a health insurance plan

Exclusion criteria

• The subject is participating in a category 1 interventional study associated with a medication, or is in a period of exclusion determined by a previous study
• The subject refuses to sign the consent
• It is impossible to give the subject informed information
• The patient is under safeguard of justice or state guardianship
• Multiple pregnancy

Trial design

97 participants in 4 patient groups

Group A

Description:

without medical history or risk factors, with a normal pregnancy

Treatment:

Other: Blood test

Group B

Description:

without medical history or risk factors, developing a pregnancy complication

Treatment:

Other: Blood test

Group C

Description:

with risk of complication, having a normal pregnancy

Treatment:

Other: Blood test

Group D

Description:

with a risk of complication, developing a pregnancy complication

Treatment:

Other: Blood test