Autophagy Markers in Endometrial Polyps

Muğla Sıtkı Koçman University

Status: Completed

Conditions: Autophagy; Endometrial Polyp

Treatments: Genetic: Beclin 1 gene

Study type: Observational

Funder types: Other

Identifiers

NCT04706000

03.09.20-08/01

Details and patient eligibility

About

The aim of this research is to evaluate autophagy markers in patients with endometrial polyps

Full description

Endometrial polyp are benign formations that are frequently encountered in gynecology practice and have malignant potential. It may be asymptomatic in the clinic or may present with abnormal uterine bleeding. Although its pathophysiology has not been clearly revealed, there are many studies in the literature about it. However, the autophagy pathway emerges as a subject that has never been evaluated. In this study, the investigators would like to prospectively evaluate Beclin 1, LC3A / B and p62 markers in the autophagy pathway in endometrial polyp tissue samples by immunohistochemistry and reveal their importance.

Enrollment: 30 patients

Sex: Female

Ages: 35+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients over 35 years of age with a histopathologically confirmed diagnosis of endometrial polyp
• patients over the age of 35 whose histopathologically reported normal endometrial biopsy results.

Exclusion criteria

• Are under the age of 35,
• those with cognitive dysfunction,
• diagnosed with any type of cancer
• who are under treatment for cancer,
• diabetes mellitus,
• hypertension,
• endometriosis,
• adenomyosis,
• chronic endometritis,
• have an acute or chronic illness,
• patients who have smoked and used alcohol in the last 10 years

Trial design

30 participants in 2 patient groups

Study group

Description:

endometrial polyp

Treatment:

Genetic: Beclin 1 gene

Control group

Description:

normal endometrium

Treatment:

Genetic: Beclin 1 gene