Avastin for CNV Secondary to Pattern Dystrophy

University of Trieste

Status and phase: Unknown; Phase 3; Phase 2

Conditions: Choroidal Neovascularization Secondary to Pattern Dystrophy

Treatments: Procedure: intravitreal triamcinolone injection of avastin (1.25 mg)

Study type: Interventional

Funder types: Other

Identifiers

NCT00391144

1/2006

Details and patient eligibility

About

The natural history of subfoveal CNV secondary to Pattern Dystrophy is little understood, but it seems that visual function may be preserved only in the short-term follow-up, with progressive deterioration thereafter.

Photodynamic therapy with verteporfin is the most studied therapeuthic option for this kindf of lesion, but unfortunately, this approach does not appear to guarantee long-term vision stabilization, and alternative therapies should be investigated.

Full description

Diagnosis of Pattern Dystrophy Diagnosis of subfoveal CNV Intravitreal injection of avastin (1.25 mg) in operating room under sterile condition.

Retreatment on the basis of the detection of disease progression and of lack of central retinal thickness reduction on OCT.

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of RPD (hyperpigmented yellowish-greyish network, other family members sharing RPD, normal electroretinogram and normal/subnormal electrooculogram)
• classic or occult CNV involving the foveal avascular zone's geometric centre

Exclusion criteria

• conditions other than RPD
• intraocular surgery or capsulotomy within the last 2 or 1 months
• pregnancy

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: Single Blind