Awaken Prone Positioning Ventinlation in COVID-19 Patients

Southeast University, China

Status

Completed

Conditions

COVID-19

Treatments

Procedure: Awaken prone positioning ventilation

Study type

Interventional

Funder types

Other

Identifiers

NCT05677984

20221227

Details and patient eligibility

About

Awaken prone positioning (APP) ventilation has been widely accepted as a standard regimen in the management of COVID-19 patients. Physiological studies have proved ventilation/perfusion improvement during APP in COVID-19, which was associated improved oxygenation. However, the optimal duration for APP was not yet demonstrated. In this study, we aimed at the prolonged APP to see whether this could improve patients outcomes.

Enrollment

409 patients

Sex

All

Ages

18 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Aged > 18-yr to 85-yr
Severe COVID-19 pneumonia (with typical radiographic alternations) and non-intubated patients.
SpO2 <= 93% with ambient air at rest.
PaO2/FiO2 <= 300 mmHg

Exclusion criteria

Definite intolerance to APP (e.g. pregnancy, extremity deformity, recent fracture, open thoracic or abdominal surgery, pace-maker implant in recent 48-hr, spine stability, pelvis or facial fractures, predicted difficult airway)
morbidity obesity, BMI > 40
consciousness disorder (GCS < 13), delirium dementia
hemodynamic instability (with norepinephrine >20 ug/min )
NYHA Grade III or IV
Severe hemoptysis
long term home oxygenation of CPAP
Refuse invasive mechanical ventilation (DNI DNR)