Awareness and Attitudes Regarding Prenatal and Preimplantation Genetic Diagnosis for Inherited Breast/Ovarian Cancer Risk

Memorial Sloan Kettering Cancer Center (MSK)

Status: Completed

Conditions: Breast Cancer; Ovarian Cancer

Treatments: Behavioral: questionnaire, interview

Study type: Observational

Funder types: Other

Identifiers

NCT00735150

06-137

Details and patient eligibility

About

We are inviting you to participate in a study of how people who have had genetic counseling for breast/ovarian cancer risk feel about certain reproductive technologies, preimplantation genetic diagnosis (PGD) and prenatal genetic diagnosis (PND), that may reduce the chances of passing increased risk onto one's children. We would also like feedback from patients who have been to our clinic in the past on the best ways to talk about PGD and PND during genetic counseling sessions. We are seeking both the opinions of people who are interested in these technologies and those who are not. It does not matter whether you have heard of PGD or PND before - you can still participate. Your past experience with genetic counseling is valuable to us in deciding how to communicate this information during sessions.

Enrollment: 34 patients

Sex: All

Ages: 18 to 39 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Females and males who are carriers of deleterious mutations in the genes BRCA1 or BRCA2.

• Over age 18 and:

  1. For women, less than 43
  2. For men, less than 50.

• Received genetic testing and counseling for BRCA.

• Fluent in English.

Exclusion criteria

• Patients who are currently under treatment (chemotherapy, radiation)
• Individuals who refuse to discuss reproductive issues.
• Unable to give informed consent due to physical, cognitive, or psychiatric disability

Trial design

34 participants in 1 patient group

1

Description:

25 female and 5 male BRCA carriers

Treatment:

Behavioral: questionnaire, interview