Axillary Approach to Brachial Plexus Blockade Using Ketamine, Regional Versus Intravenous Administration

National and Kapodistrian University of Athens

Status: Unknown

Conditions: Branchial Plexus Blockade; Anesthesia

Treatments: Procedure: Forearm surgey; Drug: Ketamine; Drug: Ropivacaine

Study type: Interventional

Funder types: Other

Identifiers

NCT05297422

877/14-01-2022

Details and patient eligibility

About

The purpose of this study is to assess Ketamine as an adjuvant to Branchial Plexus Blockade.

Full description

After being informed about the study, patients giving written informed consent will undergo anaesthesia using the Ultrasound Guided Axillary Approach to Brachial Plexus Blockade, in order to undergo forearm surgery. The purpose of this study is to assess whether Ketamine as an adjuvant lengthens sensory and motor blockade and whether it has an effect on "rebound pain" when the anaesthetic effect fades. Therefore the study will compare intravenous, regional and no administration of Ketamine as an adjuvant to Branchial Plexus Blockade. Patients will be asked to fill in a Pain VAS (Visual Analog Scale) for 24 hours following the intervention, in order to assess effectiveness of each anaesthetic method. Side effects, onset time, motor blockade score and rescue dose are also recorded.

Enrollment: 81 estimated patients

Sex: All

Ages: 16 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• BMI 20-35
• ASA score I, II, III

Exclusion criteria

• Mental disorder
• Peripheral neuropathy
• Severe hepatic or renal disease
• Gastrointestinal bleeding history

Trial design

Primary purpose: Other

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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81 participants in 3 patient groups

Control

Active Comparator group

Description:

Axillary Approach to Brachial Plexus Blockade will be performed using 30ml Ropivacaine 0.5% ,without Ketamine as an adjuvant.

Treatment:

Procedure: Forearm surgey

Drug: Ropivacaine

Ketamine IV

Active Comparator group

Description:

Axillary Approach to Brachial Plexus Blockade will be performed using 30ml Ropivacaine 0.5% ,with Ketamine as an adjuvant 30mg intravenously.

Treatment:

Drug: Ketamine

Procedure: Forearm surgey

Drug: Ropivacaine

Ketamine Regional

Active Comparator group

Description:

Axillary Approach to Brachial Plexus Blockade will be performed using 30ml Ropivacaine 0.5% ,with Ketamine as an adjuvant 30mg regionally.

Treatment:

Drug: Ketamine

Procedure: Forearm surgey

Drug: Ropivacaine