Axillary Nodal Burden in HER2+ and TNBC

Yonsei University Health System (YUHS)

Status: Completed

Conditions: Breast Cancer

Treatments: Procedure: Breast conserving surgery with axillary surgery

Study type: Observational

Funder types: Other

Identifiers

NCT07211451

3-2025-0126

Details and patient eligibility

About

This study aimed to evaluated rates of pathologic axillary nodal metastasis in patients with with early-stage HER2-positive BC or TNBC who had clinically node-negative status on preoperative ultrasonography and underwent upfront breast-conserving surgery (BCS) with axillary surgery. In addition, this study aimed to identify subgroups in which SLNB omission may be feasible.

Enrollment: 1,571 patients

Sex: Female

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• HER2-positive breast cancer or TNBC
• Patients who received upfront breast conserving surgery with axillary surgery
• Patients who had a clinically axillary node negative disease

Exclusion criteria

• Patients who underwent mastectomy
• Absence of axillary nodal assessment on ultrasonography
• Patients who underwent mastectomy
• Patients who underwent mastectomy