AZD2171 in Treating Patients With Relapsed or Refractory B-Cell Chronic Lymphocytic Leukemia

National Cancer Institute (NCI)

Status and phase

Completed

Phase 2

Conditions

Refractory Chronic Lymphocytic Leukemia

B-cell Chronic Lymphocytic Leukemia

Treatments

Other: laboratory biomarker analysis

Drug: cediranib maleate

Study type

Interventional

Funder types

NIH

Identifiers

NCT00321724

NCCTG-N048F

NCI-2012-01825

CDR0000467560 (Registry Identifier)

U10CA025224 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This phase II trial is studying how well AZD2171 works in treating patients with relapsed or refractory B-cell chronic lymphocytic leukemia. AZD2171 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the cancer cells

Full description

OBJECTIVES:

I. Evaluate the response rate in patients with relapsed or refractory B-cell chronic lymphocytic leukemia (B-CLL) treated with AZD2171.

II. Evaluate the toxicity of AZD2171 in patients with relapsed or refractory B-CLL.

III. Evaluate the complete response rate, progression-free and overall survival distributions, and duration of response in patients with relapsed or refractory B-CLL treated with AZD2171.

IV. Assess vascular endothelial growth factor receptor-2 (VEGFR-2) protein and phosphorylation levels in B-CLL cells using pretreatment samples and evaluate the association between Rai stage at study entry and clinical response to AZD2171.

V. Perform preclinical testing of AZD2171 in the induction of B-CLL cell apoptosis/cell death using pretreatment samples, and evaluate the ability to downregulate the phosphorylation status of VEGFR-2 of B-CLL cells by comparing in vitro samples with and without AZD2171.

VI. Study the differences in in vitro levels of B-CLL cell apoptosis/cell death and alteration of VEGFR-2 phosphorylation using pretreatment samples with and without AZD2171 and how these differences correlate with clinical outcomes.

VII. Assess if the clinical responses are associated with changes in bone marrow vascularity.

OUTLINE: This is a multicenter study.

Patients receive oral AZD2171 once daily on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Patients undergo blood sampling and biopsies at baseline and periodically throughout study for biomarker and correlative studies.

After completion of study therapy, patients are followed periodically for up to 5 years from study entry.

Enrollment

35 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Histological confirmation of B-cell chronic lymphocytic leukemia (B-CLL)
- Peripheral blood lymphocyte count > 5,000/mm³
- Small to moderate peripheral blood lymphocytes with ≤ 55% prolymphocytes
- Bone marrow aspirate with ≥ 30% lymphoid cells
- Monoclonality of B lymphocytes by immunophenotyping, demonstrating all of the following:
  - B-cell markers with CD5 antigen in the absence of other pan-T-cell markers (CD3, CD2, etc.)
  - CD19 and/or CD20
  - Expression of CD23 on the CLL cells OR dim B-cell expression of kappa or lambda light chains
Disease must be refractory to or progressive after treatment with at least 1 course containing a purine nucleoside analog (e.g., fludarabine, cladribine, or pentostatin)
Life expectancy > 6 months
ECOG performance status (PS) 0-2 OR Karnofsky PS 60-100%
Absolute neutrophil count ≥ 1,500/mm³
Platelet count ≥ 50,000/mm³
Hemoglobin ≥ 8 g/dL
Bilirubin ≤ 1.5 times upper limit of normal (ULN)
- Patients with Gilbert's syndrome may have a bilirubin ≥ 1.5 times ULN
AST and ALT ≤ 2.5 times ULN
Creatinine ≤ 1.5 times ULN
Not pregnant or nursing
Negative pregnancy test
Fertile patients must use effective contraception
No history of allergies to compounds similar to AZD2171
QTc prolongation < 500 msec
No other significant ECG abnormality
No history of familial long QT syndrome
Proteinuria < 1+ by dipstick OR protein < 1 g/24 hr urine collection
No known HIV positivity
No New York Heart Association (NYHA) class III or IV disease
- NYHA class II disease controlled with treatment and monitoring allowed
No other uncontrolled illness including, but not limited to, the following:
- Hypertension
- Ongoing or active infection
- Symptomatic congestive heart failure
- Unstable angina pectoris
- Cardiac arrhythmia
- Psychiatric illness or social situations that would limit compliance
See Disease Characteristics
More than 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin C), radiotherapy, anti-vascular endothelial growth factor (VEGF) treatment, or major surgery and recovered
More than 30 days since prior investigational agents
No concurrent drugs or biologics with proarrhythmic potential
No other concurrent investigational agents
No other concurrent anticancer therapy